On the outside, Sanada looks meek and gloomy. He gets push around by his students and is easily startled. In truth, he is a skilled and strong warrior with a calm and deadly mind. He is a tactician master holding the absolute and undying loyalty of the Jūyūshi. Sanada likes to go by the name Nobushige instead of Yukimura because it helps him hide is true identity.
Sanada has long black hair and blue eyes with glasses. His hair is unkempt and long to cover most of his forehead. Sanada, for the most part, always have an emotionless face on. He only get serious when he needs to be.
When Sanada fuse with his Oni Engetsu, he has the appearance of a mystical beast fuse in human form. He grows animal ears and even have a horn on his forehead.
Sanada is strong even without the help of his Oni and the Jūyūshi. One kick from him can instantly kill a normal person. With the help of his Oni, Sanada strength becomes equal to Sakura fused with Tachibana's power.
When Sanada fuse with his Oni to transform into an animal humanoid which increase his power and speed.
Sanada first appear in Chapter 6 where he is approach by the resident of Urashichicken. After he dismisses his class, Sanada quickly lore Hana, Tachibana, Sakura, and Chika into his domain and ambush them with the Jūyūshi. There, he question Sakura as to why Urashichicken has seek an audience with him. Sakura reveal to him that in order to obtain Nobunaga's Oni, the strongest Oni, one must have a huge number of Oni at his side. Sakura ask that Sanada and the Jūyūshi join up with Hidetsugu of Hideyoshi to fight against Iemitsu of Tokugawa. Sanada answer to Sakura was that they won't serve under the weak. In order to prove that the Hideyoshi is worthy of serving, Sakura must overcome Sanada on a one on one fight. After a fierce battle between Sanada and Sakura, Sakura was able to prove to Sanada the strength of Hidetsugu. Sanada then decided to join forces with Hidetsugu.
In the Sengoku Period, Sanada Yukimura is famous for his service under the Toyotomi daimyo in the Siege of Osaka. After Hidoyoshi Toyotomi died, Ieyusa Tokugawa begin to take control of Japan. Fearing that the Toyotomi will pose a threat to his regency, Tokugawa prepared an army of more than 30,000 solders to attack the Toyotomi castle at Osaka. With 7000 men, Sanada Yukimura was able to repel and break through Tokugawa's 30,000 solders, leading Tokugawa to resort to an artillery attack instead of an invasion. After the artillery fail to destroy the castle, Tokugawa sued for peace in the condition that the Toyotomi destroy their castle's outer moat. Agreeing to the terms, the Hideyori Toyotomi let Tokugawa's envoy in. But instead of just destroying the outer moat, his envoy also destroyed the inner moat as well, leaving the castle vulnerable. After Ieyasu successfully disassemble the castle defense, he once again order an all out invasion of Toyotomi's castle. At the Battle of Dōmyōji, Sanada engage in battle against Date Masamune, who served Tokugawa at that time, and lost due to the blunder of his officers. Sanada then decided to retreat back to Osaka castle to regroup. Soon, Sanada entered another battle once more which he sustain heavy injuries. Sanada retreated towards a shrine to tend his wounds but Tokugawa's troops came after him. Despite his injuries, Sanada was able to kill all of the soldiers that Tokugawa sent. But being too injured to fight on, Sanada committed seppuku and died in June 3, 1615 (Age 47-48). The grave of Sanada Yukimura is located in Yasui Shrine located to the west of Shitennoji Temple in Osaka.